Van de Ven Double Ends The Toffees' Run at Brand New Home Ground
The Dutch defender emerged as the first defender to net twice in a English top-flight game for Tottenham since Jan Vertonghen in March 2013.
Match summary
The Spurs defender heads home twice in opening period
Everton's defender has equalizer disallowed after video check
Senegalese midfielder nets third in dying moments
The defeat is Everton's first at Hill Dickinson Stadium
Micky van de Ven scored on two occasions as Tottenham extended their winning streak in away games in the top division and delivered Everton their initial loss at their new home.
The Toffees were undefeated in their five previous fixtures at their new ground at the dockside location, having departed their historic home behind after 133 years at the end of last season.
But Spurs captain Van de Ven struck twice from corners in the opening 45 minutes to place their strong form at risk, and they were unable to turn it around before Pape Matar Sarr - set up by former Toffees attacker Richarlison - nodded in a third to seal the victory.
Jake O'Brien thought he had levelled the scores five minutes after the defender's first goal, glancing a powerful header past the Spurs keeper from an Everton corner.
Beto, meanwhile, missed a number of chances, while the Italian goalkeeper made a succession of excellent saves to ensure Tottenham went five away games without defeat in the Premier League.
But the video assistant referee stepped in, instructing the match official to review the score on the pitchside monitor and the official ruled that Jack Grealish and Iliman Ndiaye were in offside positions and had interfered with the Spurs keeper.
This victory elevates Thomas Frank's team up to third in the Premier League, five points off north London rivals and table-toppers Arsenal.
The Merseyside club stay in 14th position and sit half a dozen points ahead of the relegation zone.
Tottenham analysis: Van de Ven fulfils duties at each end of pitch
After a drab midweek performance in the Champions League against Monaco, where they managed a mere attempts on goal, Frank chose the French striker in attack instead of ex-Everton forward the Brazilian.
The new arrival was unable to influence the game before being replaced for the substitute after 60 minutes on the field, but it turns out he wasn't needed in the end.
Centre-back Van de Ven converted into an attacking force to be feared.
Spurs' first goal came from a well-worked set-piece play, with Rodrigo Bentancur heading the ball back across the six-yard box for an free Van de Ven to score.
And Ven de Ven - filling in as captain in Cristian Romero's unavailability - notched his next goal in added time as he rose above the England keeper to nod in.
The Dutchman was just as impressive in defence, partnering well with his defensive colleague as the duo handled excellently with the 34 crosses sent their way by the opposition.
Toffees breakdown: Everton missing finishing touch
Everton's new home had been a happy hunting ground, but it seems the freshness may have worn off slightly and fans flocked to the exits after Sarr's third for Spurs.
The break in the team's winning streak at home will not be a major concern for David Moyes, but their striker situation are.
Beto and the other striker - the Everton's two established strikers - had scored just one league goal between them before Sunday's outing.
And they were failed to add to that poor tally on a wet and gloomy night on in Liverpool.
The striker's performance was epitomized when he opted to overhead kick a clear chance from close range, despite having room and time to readjust for a more conventional attempt that would have tested the keeper.
Barry, as well, was unable to make an impact after coming on for the starter in the second half.
It was not for a shortage of chance. The majority of Everton's offensive moves came through Grealish and Ndiaye, who relentlessly whipped dangerous balls into the Spurs penalty area.
What next for both teams?
The Toffees: Moyes' men head to Sunderland in the Premier League on Monday, 3 November at 8 PM.
Spurs: Spurs travel to Newcastle's ground on Wednesday, 29 October for their next round League Cup tie against the Magpies.